Prenatal diagnosis of single umbilical artery: implications for chromosomal abnormalities and neonatal outcome.
- Author:
Qingxian CHANG
1
;
Cuihua CHEN
;
Mei ZHONG
;
Yuwen QIU
;
Chaoqun XIAO
;
Qitao HUANG
;
Yanhong YU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Chromosome Disorders; diagnostic imaging; genetics; Female; Fetus; abnormalities; Humans; Karyotyping; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Single Umbilical Artery; diagnostic imaging; Ultrasonography, Prenatal; Young Adult
- From: Journal of Southern Medical University 2013;33(3):451-453
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the implications of a prenatal diagnosis of single umbilical artery (SUA) for chromosomal abnormalities and neonatal outcomes.
METHODSFrom January, 2008 to June, 2012, color Doppler ultrasound identified 44 fetuses with SUA. Prenatal diagnoses with amniocentesis or umbilical blood sampling were subsequently ordered for routine chromosome karyotyping and the newborns were followed up for assessing the neonatal outcomes.
RESULTSOf all the 44 fetuses, 24 had uncomplicated SUA, and 20 had other concurrent abnormalities (including 8 with abnormal ultrasound soft indexes and 12 with chromosomal abnormalities). The two groups of fetuses showed significant differences in gestational weeks at delivery and incidence of chromosomal abnormalities but not in neonatal weight, placenta weight or APGAR score.
CONCLUSIONSFetuses with a prenatal diagnosis of SUA and other development abnormities need to undergo prenatal chromosomal examination. For fetuses with uncomplicated SUA, careful ultrasound examination is necessary to avoid missed diagnosis of potential congenital abnormalities.
