ROS kinase fusions are not common in Chinese patients with cholangiocarcinoma.
- Author:
Pengmin LIU
1
;
Yajun WU
;
Li SUN
;
Qiang ZUO
;
Min SHI
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, Differentiation, B-Lymphocyte; genetics; metabolism; Bile Duct Neoplasms; metabolism; pathology; Carrier Proteins; genetics; metabolism; Cholangiocarcinoma; metabolism; pathology; Female; Gene Expression; Histocompatibility Antigens Class II; genetics; metabolism; Humans; Male; Membrane Proteins; genetics; metabolism; Middle Aged; Oncogene Proteins, Fusion; genetics; metabolism; Paraffin Embedding; Protein-Tyrosine Kinases; genetics; metabolism; Proto-Oncogene Proteins; genetics; metabolism; Sodium-Phosphate Cotransporter Proteins, Type IIb; genetics; metabolism
- From: Journal of Southern Medical University 2013;33(4):474-478
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the expressions of different forms of ROS fusions in Chinese patients with cholangiocarcinoma (CCA).
METHODSRT-PCR was employed to examine formalin-fixed and paraffin-embedded CCA samples from stage I-IV patients for detection of ROS fusions involving Fused in Glioblastoma (FIG), solute carrier protein (SLC34A2) and major histocompatibility complex class II invariant chain (CD74). Serpin peptidase inhibitor clade A member 1 (SERPINA1) was detected as the reference gene.
RESULTSIn all the 56 CCA samples, 80.4% (45/56) were positive for SERPINA1 expression as evaluable samples. Of these evaluable samples, none expressed the ROS fusions.
CONCLUSIONROS fusions are not common in Chinese CCA patients.
