Intervention of nicotinamide on skin melanin genesis after UVA exposed.
- Author:
Muhammad PATAM
1
;
Xi-peng JIN
;
Yu-bin ZHANG
;
Jian-ying PAN
;
Guang-zu SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Cells, Cultured; Humans; Melanins; biosynthesis; Melanocytes; drug effects; metabolism; radiation effects; Niacinamide; pharmacology; Ultraviolet Rays; adverse effects
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2007;25(8):465-469
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the interference effect of nicotinamide on UVA-induced melanin genesis and melanin transport in human skin melanocyte.
METHODSThe optimum UVA dose expected to cause cell proliferation: 0.2 J/cm(2), nicotinamide was added immediately after the 0.2 J/cm(2) UVA exposure and the melanin content, cell cycles, cell apoptosis and mRNA express level were measured respectively.
RESULTSMelanin content in melanocytes was increased significantly after exposed to 0.2 J/cm(2) UVA. Melanin content in melanocytes was decreased after treatment with 10.0 mmol/ml nicotinamide following UVA exposure, but the cell cycles and the cell apoptosis rate were not significantly altered. mRNA express levels of TYR, TRP-1 were modulated by nicotinamide.
CONCLUSIONNicotinamide has more effect on decreasing melanin genesis after UVA exposure, nicotinamide also plays a role in modulating the mRNA express of TYR, TRP-1 gene. It is possible to consider nicotinamide as an efficient and safe sun screen to provide a certain level of protection for UVA exposed skin.
