Evaluation of Portal Hypertension: A Comparison of the Use of Liver Perfusion CT with Wedge Hepatic venous Pressure and Hepatic venous Pressure Gradient.
10.3348/jkrs.2008.59.3.173
- Author:
Dong Jin CHUNG
1
;
Young Joong KIM
;
Yong Sung PARK
;
Tae Hee LEE
;
Chong Soo KIM
;
Heung Keun KANG
Author Information
1. Department of Radiology, University of Konyang College of Medicine, Korea. bookdoo7@chollian.net
- Publication Type:Original Article
- Keywords:
Computed tomography (CT), perfusion study;
Liver cirrhosis;
Hypertension, portal;
Hepatic veins
- MeSH:
Catheterization;
Catheters;
Fibrosis;
Hepatic Veins;
Humans;
Hypertension, Portal;
Liver;
Liver Cirrhosis;
Liver Cirrhosis, Alcoholic;
Perfusion;
Venous Pressure
- From:Journal of the Korean Radiological Society
2008;59(3):173-181
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We compared the hepatic perfusion indices obtained using hepatic perfusion CT with the wedge hepatic venous pressure (WHVP) and hepatic venous pressure gradient (HVPG) to determine the efficacy of the use of liver perfusion CT for the evaluation of portal hypertension. MATERIALS AND METHODS: Thirty-five patients with liver cirrhosis underwent hepatic vein catheterization to measure WHVP and HVPG and underwent a liver perfusion CT examination. Arterial perfusion, portal perfusion, total perfusion and the hepatic perfusion index (HPI) were calculated by the methods described by Miles and Blomley. The overall correlation coefficients (r) between the perfusion indices and WHVP and HVPG were calculated. An additional correlation coefficient of 23 alcoholic cirrhosis patients was calculated. RESULTS: Using Blomley's equation, HPI had a positive correlation with WHVP (r = .471; p < .05) and HVPG (r = .482; p < .05). For the alcoholic liver cirrhosis patients, HPI had a higher positive correlation with WHVP (r = .500; p < .05) and HVPG (r= .539; p < .05) than for the non-alcoholic cirrhosis patients. There was no statistical difference between the use of Miles' equation and Blomley's equation for the evaluation of portal hypertension. CONCLUSION: This preliminary study showed that HPI positively correlated with WHVP and HVPG, especially in alcoholic cirrhosis patients. Liver perfusion CT may be useful in the evaluation of portal hypertension.
