Antimicrobial effects of erythromycin microspheres against Mycoplasma Pneumoniae in rats.
- Author:
Tao LI
1
;
Jing WEN
;
Wen-ling JIANG
;
Ming GONG
;
Zhan-qiu YANG
;
Hong XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Erythromycin; administration & dosage; Male; Microspheres; Mycoplasma pneumoniae; drug effects; Pneumonia, Mycoplasma; drug therapy; Random Allocation; Rats; Rats, Wistar
- From: Journal of Southern Medical University 2008;28(10):1875-1877
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the antimicrobial effects of erythromycin microspheres against Mycoplasma pneumoniae in rats.
METHODSWith erythromycin lactobionate as the positive control, erythromycin microspheres at 3 non-toxic doses (0.1, 0.5, and 1.2 g.kg(-1).d(-1)) were administered intragastrically for 6 consecutive days in Wistar rats with Mycoplasma pneumoniae infection. The general condition and lung index of the rats were observed and measured to assess the therapeutic effects of the treatments against Mycoplasma pneumoniae infection.
RESULTSThe erythromycin microspheres at 0.1, 0.5, 1.2 g.kg(-1).d(-1) significantly alleviated the symptoms of the rats infected with Mycoplasma pneumoniae and reduced the pulmonary index of the infected rats from 1.75 to 1.45, 1.38 and 1.25, respectively (P < 0.01). An obvious dosage-effect relationship was noted between the dose of erythromycin microsphere and the tissue pathologies due to the infection.
CONCLUSIONErythromycin microspheres possess strong activity against Mycoplasma pneumoniae in rats.
