Effects of bagasse polysaccharide on the immune functions of immunosuppressed mice.
- Author:
Qiang LIU
1
;
Yu-hong SONG
;
Hui LI
;
Yu CAI
;
Xue-gang SUN
;
Zhi-liang CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cellulose; chemistry; Cyclophosphamide; Female; Immunocompromised Host; immunology; Lymphocyte Activation; drug effects; Macrophages; immunology; Male; Mice; Phagocytosis; drug effects; Polysaccharides; pharmacology; Random Allocation
- From: Journal of Southern Medical University 2008;28(10):1911-1913
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of bagasse polysaccharide on the immune functions of immunosuppressed mice.
METHODSImmunosuppressed mouse models were established by intraperitoneal injections with cyclophosphamide followed by daily intragastric administration of bagasse polysaccharide. After the treatments, the mice were examined for immune organ weight index, phagocytotic function of the macrophages, delayed type hypersensitivity, serum IgM level following exposure to chicken red blood cells, formation of hemolytic plaques, T cell percentage and lymphocyte transformation.
RESULTSTreatment of the immunosuppressed mice with bagasse polysaccharide at the daily dose of 200 and 400 mg/kg significantly increased the weight of the immune organs, phagocytotic function of the macrophages, delayed type hypersensitivity, serum IgM level against chicken red blood cells, formation of hemolytic plaques, T cell percentage and lymphocyte transformation.
CONCLUSIONBagasse polysaccharide can enhance the immune functions of immunosuppressed mice.
