Effects of neuraxial block and general anesthesia on tumor metastasis in rats.
- Author:
Wei ZHENG
1
;
Yan-ping LI
;
Ren-chun LAI
;
Ya-li LU
;
Zhi-wen SHEN
;
Xu-dong WANG
Author Information
- Publication Type:Journal Article
- MeSH: Anesthesia, Epidural; adverse effects; Anesthesia, General; adverse effects; Animals; Breast Neoplasms; immunology; surgery; Female; Immunologic Surveillance; immunology; Ketamine; pharmacology; Lung Neoplasms; immunology; secondary; Male; Neoplasm Metastasis; Neoplasm Transplantation; Nerve Block; Propofol; pharmacology; Random Allocation; Rats; Rats, Inbred F344
- From: Journal of Southern Medical University 2008;28(12):2218-2220
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of different anesthesia methods on immune surveillance and tumor metastasis in tumor-bearing rats.
METHODSSeventy-two Fischer 344 rats were randomly assigned into 3 equal groups and anesthetized for 1 h with ketamine (group K), propofol (group P), or neuraxial block (group B). All the rats were subjected to laparotomy followed by intravenous injection of MADB106 tumor cells, and 24 h after the injection, the number and activity of circulating CD3(+), CD4(+), CD8(+), and D4(+)/CD8(+) lymphocyte subsets and NK cellèCD161a(+)éwere assessed. Three weeks later, the lung metastases were counted.
RESULTSCompared with those in group B, the numbers of CD3(+), CD4(+), CD8(+), and CD161a(+) lymphocytes and the activity of circulating NK cells were significantly reduced, and the lung metastases of MADB106 increased significantly in groups K and P (P<0.05 or 0.01 ). The activity of immune surveillance in group K was significantly lower than that in group P except for CD8(+) cells, and the tumor metastases in group K increased significantly in comparison with those in group P (P<0.05 or 0.01).
CONCLUSIONNeuraxial block provides protection of the activity of immune surveillance and reduces tumor metastases in tumor-bearing rats compared with general anesthesia.