Correlation between polymorphisms in the coagulation factor Ⅶ gene hypervariable region 4 site and the risk of coronary heart disease in population with different ethnic backgrounds: a Meta-analysis
10.3760/cma.j.issn.0254-6450.2013.012.022
- VernacularTitle:血浆凝血因子Ⅶ基因高变区4多态性与冠心病相关性的Meta分析
- Author:
Li-Li WANG
1
;
Bin MA
;
Dun QIAN
;
Jun PANG
;
Ya-Li YAO
Author Information
1. 730000,兰州大学第一医院心内科
- Keywords:
Coronary artery disease;
Polymorphisms;
Blood coagulation factors Ⅶ gene hypervariable region 4;
Meta-analysis
- From:
Chinese Journal of Epidemiology
2013;34(12):1250-1254
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the correlation between polymorphisms in the coagulation factor Ⅶ (F Ⅶ) gene hypervariable region 4 (HVR4) site and risk related to coronary heart disease (CHD) in different ethnic populations,especially the Asian populations.Methods Publications up to April 2013,from CBM,CNKI,Wanfang Database,VIP,PubMed,Cochrane Library and Embase were searched to collect data from case-control studies related to F Ⅶ gene HVR4 site and CHD in populations from different ethnicities.Quality of studies was evaluated,available data extracted and both RevMan 5.1 and Stata 11.0 softwares were used for Meta-analysis.Results Fifteen case-control studies were included,involving 3167 cases with CHD group and 3168 cases in the control group.Results on this Meta-analysis showed that:a) polymorphism of the FⅦ gene HVR4 site H7/H6 +H5and CHD,b) H7H7/H6H6 + H7H6 and CHD were both slightly correlated between people with different ethnic backgrounds.However,the H6 allele versus H7 + H5 allele and CHD showed different results-a high correlation seen in different ethnic groups.H5 allele versus H6 + H7 allele and CHD did not appear significant difference(OR=l.20,95％CI:0.76-1.90,P=0.43).Conclusion Both FⅦgene HVR4 polymorphisms H7 allele and the H7H7 genotype might have served as protective factors for CHD in different ethnic groups,H6 allele might serve as a risk factor for CHD,but H5 allele was likely not to be associated with CHD in different ethnic groups.
