Association between the single nucleotide polymorphisms of human CD36 gene and acute coronary syndrome.
- Author:
Junyi LUO
1
;
Yitong MA
2
;
Xiang XIE
1
;
Yining YANG
1
;
Xiaomei LI
1
;
Zixiang YU
1
;
Chunhui HE
1
;
Bangdang CHEN
3
;
Fen LIU
3
Author Information
- Publication Type:Journal Article
- MeSH: Acute Coronary Syndrome; epidemiology; genetics; Alleles; CD36 Antigens; genetics; China; epidemiology; Ethnic Groups; genetics; Gene Frequency; Genotype; Humans; Polymorphism, Single Nucleotide
- From:Chinese Journal of Epidemiology 2014;35(2):200-204
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe aim of the present study was to assess the association between the polymorphisms of CD36 gene and acute coronary syndrome(ACS).
METHODSGenotypes of CD36 single nucleotide polymorphisms were detected under PCR-RFLP in 522 patients with ACS and 1 215 controls.
RESULTSFor people under Han and Uygur ethnicities, the distribution of genotypes and allele of rs1722505 was significantly different between ACS and the controls(all P < 0.05). For Han population, the frequency of A allele of rs17154181 was significantly lower in ACS group than that in the control group(P = 0.034). Results from logistic regression analysis showed that the AA+AG genotype of rs1722505 was significantly higher in ACS patients than that in controls both between the Hans and the Uygurs(OR = 1.436, 95%CI:1.047-1.970, P = 0.025;OR = 1.589, 95%CI:1.009-2.473, P = 0.046, respectively). For Han people,AA+AG genotype of rs17154181 was significantly lower in ACS patients than that in controls(OR = 0.667, 95% CI:0.494-0.900, P = 0.008).
CONCLUSIONData from the present study suggested that the CD36 gene might serve as a genetic marker of ACS in both Han and Uygur populations.
