Research progress of anemia associated with inflammatory bowel diseases.
- Author:
Zhi-wu HONG
1
;
Jian-an REN
Author Information
1. Nanjing University School of Medicine, Nanjing, China.
- Publication Type:Journal Article
- MeSH:
Anemia;
diagnosis;
etiology;
therapy;
Humans;
Inflammatory Bowel Diseases;
complications
- From:
Chinese Journal of Gastrointestinal Surgery
2012;15(6):644-647
- CountryChina
- Language:Chinese
-
Abstract:
Anemia is a frequent and serious complication in patients with inflammatory bowel disease (IBD). One third of patients with inflammatory bowel disease suffers from recurrent anemia. Anemia is associated with a decrease in the quality of life and an increased rate of hospitalization. A number of studies have been conducted and the most relevant conclusions obtained are:(1)anemia is quite common in IBD; (2)although in many cases anemia parallels the clinical activity of the disease, many patients in remission have anemia, and iron, vitamin B12 and/or folic acid deficiency;(3)anemia, and also iron deficiency without anemia, have important consequences in the clinical status and quality of life of the patients;(4)oral iron supplement is limited by poor absorption, intolerance, and induction of oxidative stress at the site of bowel inflammation; (5) intravenous iron sucrose has a high efficiency and a significant improvement in the quality of life; (6)erythropoietin is needed in a significant number of cases to achieve normal hemoglobin levels. Combination therapy with erythropoietin leads to a faster and larger hemoglobin increase. Thus, clinicians caring for IBD patients should have a comprehensive knowledge of anemia, and apply recently published guidelines in clinical practice.
