Study on preparation of ginkgolides component solid dispersions micro pill drug release unit.
- Author:
Dan LIU
;
Zhen-Hai ZHANG
;
Xiao-Yun CHEN
;
Xiao-Bin JIA
- Publication Type:Journal Article
- MeSH:
Cellulose;
chemistry;
Chitosan;
chemistry;
Drug Compounding;
methods;
Ginkgolides;
chemistry
- From:
China Journal of Chinese Materia Medica
2014;39(6):1002-1006
- CountryChina
- Language:Chinese
-
Abstract:
Microcrystalline cellulose and chitosan were applied to prepare ginkgolides component solid dispersions micro pill drug release unit and study the dissolution of GKS. Microcrystalline cellulose, chitosan as composite carrier, solvent method was used to prepare ginkgolides component solid dispersions. Differential scanning calorimetry was used to Characterization of ginkgolides component solid dispersions. Ginkgolides component solid dispersions as principle agent were prepared for micro-pellet. Comparison of different types, different doses of the adhesive, drug-polymer interactions, and disintegrating agent for the preparation of ginkgolides components of micro-pellet drug release unit, the optimum preparation ginkgolides components of micro-pellet drug release unit was screened by orthogonal design experiment. Preparation of ginkgolides components solid dispersions with microcrystalline cellulose and chitosan at ratio 1: 3. Drug cumulative dissolution was more than 80% in 60 min. Solid dispersion-micro-pellet drug release unit can significantly improve the dissolution of ginkgolides components, it has practical application value.
