Study on decoction's effect of different processed rhizomes of Cibotium barometz on retinoic acid induced male rats osteoporosis.
- Author:
Gang XU
;
Na SUN
;
Min-Jie ZHAO
;
Cheng-Guo JU
;
Tian-Zhu JIA
- Publication Type:Journal Article
- MeSH:
Animals;
Biomarkers;
blood;
Chromatography, High Pressure Liquid;
Drug Compounding;
methods;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
therapeutic use;
Male;
Osteoporosis;
blood;
chemically induced;
drug therapy;
Pteridophyta;
chemistry;
Rats;
Rats, Sprague-Dawley;
Rhizome;
chemistry;
Tretinoin;
adverse effects
- From:
China Journal of Chinese Materia Medica
2014;39(6):1011-1015
- CountryChina
- Language:Chinese
-
Abstract:
This study compared the decoction's HPLC figures of the different processed rhizomes of Cibotium barometz including the raw, the sand-baked, the wined, the steamed and the salted, on the basis of which, with the sand-baked Drynaria fortunei decoction as the positive control group, comparingall groups' decoction, concentration of which was 104.2 g x L(-1), for 4 weeks, by their effects (s-TRAP and total scores of OPG, Ca, P, IL-6, TNF-alpha and IL-1) on retinoic acid induced male rats osteoporosis. The experiment results showed the sand-baked and the wined were better than the steamed, the salted and the raw;in the processing methods' selection, the sand-baked was a better heating method than the steamed and the rice wine was the better excipient than the salt. It provided a reference to explain the processing principle of rhizomes of C. barometz and work mechanism of anti-osteoporosis.
