Chemical constituents of leaves of Psidium guajava.
- Author:
Meng SHAO
;
Ying WANG
;
Yu-Qing JIAN
;
Xue-Gang SUN
;
Xiao-Jun HUANG
;
Xiao-Qi ZHANG
;
Wen-Cai YE
- Publication Type:Journal Article
- MeSH:
Drugs, Chinese Herbal;
chemistry;
Organic Chemicals;
analysis;
Plant Leaves;
chemistry;
Psidium;
chemistry
- From:
China Journal of Chinese Materia Medica
2014;39(6):1024-1029
- CountryChina
- Language:Chinese
-
Abstract:
To study the chemical constituents of the 95% ethanol extract of Psidium guajava. Compounds were separated by using a combination of various chromatographic methods including silica gel, D101 macroporous resin, ODS, Sephadex LH-20 and preparative HPLC. Their structures were elucidated by physicochemical properties and spectral data Eighteen compounds were isolated and identified as (+) -globulol (1), clovane-2beta, 9alpha-diol (2), 2beta-acetoxyclovan-9alpha-ol (3), (+) -caryolane-1 ,9beta-diol (4), ent-T-muurolol (5), clov-2-ene-9alpha-ol (6), isophytol (7), tamarixetin (8), gossypetin (9), quercetin (10), kaempferol (11), guajaverin (12), avicularin (13), chrysin 6-C-glucoside (14), 3'-O-methyl-3, 4-methylenedioxyellagic acid 4'-O-beta-D-glucopyranoside (15), p-hydroxy-benzoic acid (16), guavinoside A (17) and guavinoside B (18). Compounds 2-9 and 14-16 were isolated from this plant for the first time. The ethanol extract showed 61.3% inhibition against the proliferation of colon cancer cell line SW480.
