Comparation of gastrointestinal absorption studies of specnuezhenide with salidroside in rats.
- Author:
Hui-Fen LI
;
Xue-Lan ZHANG
- Publication Type:Journal Article
- MeSH:
Animals;
Chemistry, Pharmaceutical;
Gastrointestinal Tract;
metabolism;
Glucosides;
chemistry;
metabolism;
Intestinal Absorption;
Male;
Phenols;
chemistry;
Pyrans;
chemistry;
metabolism;
Rats;
Rats, Sprague-Dawley
- From:
China Journal of Chinese Materia Medica
2014;39(6):1107-1110
- CountryChina
- Language:Chinese
-
Abstract:
The experiment was designed to study the mechanism of increasing efficiency of Ligustrum lucidum steamed with wine. Rats in vivo with gastrointestinal perfusion model were used. The contents of salidroside and specnuezhenide in the fluid of gastrointestinal perfusion of rats were measured by HPLC at different time points after dosing. Then the K(a) and absorption percentage were calculated. Specnuezhenide could be detected in the fluid of gastrointestinal perfusion of specnuezhenide. The K(a) of the specnuezhenide and salidroside in the fetal intestines are 0.055 3 and 0.144 2 h(-1) respectively and the total absorptivity are 24.46% and 60.14% respectively after 4 hours. The K(a) in the stomach are 5.70 and 8.26 h(-1) respectively and the total absorptivity are 34.21% and 47.23% respectively after 4 hours. The experiment proved that specnuezhenide can be metabolized into salidroside which is more beneficial for gastrointestinal absorption. The experiment proved that specnuezhenide can be metabolized into salidroside both in the rat's stomach and the fetal intestine and compared with the specnuezhenide salidroside is more conducive to gastrointestinal absorption. The results suggested that the increasing efficiency on liver and kidney of L. lucidum steamed with wine has business with the fact that Specnuezhe nide is more conducive to the body after it is changed into salidroside.
