Effect of neoadjuvant chemotherapy on the postoperative pulmonary infection of patients with advanced gastric cancer.
- Author:
Chao-gang FAN
1
;
Guo-li LI
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Chemotherapy, Adjuvant; Female; Humans; Male; Middle Aged; Pneumonia; etiology; Postoperative Complications; Stomach Neoplasms; drug therapy; surgery
- From: Chinese Journal of Gastrointestinal Surgery 2011;14(7):503-505
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of neoadjuvant chemotherapy on the postoperative pulmonary infection of patient with gastric cancer.
METHODSBetween January 2009 and January 2011, 139 patients with curable stage T2N2 or T3N2 gastric cancer were randomly assigned to group 1(69 cases, neoadjuvant chemotherapy with combined preoperative intraarterial infusion and intravenous chemotherapy before gastrectomy and D2 lymphadenectomy) and group 2(70 cases,gastrectomy and D2 lymphadenectomy alone). The morbidity of postoperative pneumonia in the two groups were recorded respectively.
RESULTSThe two groups were similar with respect to various clinical or pathological characteristics. All the patients underwent gastrectomy and D2 lymphadenectomy successfully. Eight patients in group 1 suffered from the postoperative pneumonia, accounting for 11.6%. Nine patients in group 2 suffered from the postoperative pneumonia, accounting for 12.9%. There was no significant difference between the two groups about the incidence of postoperative pneumonia.
CONCLUSIONSurgery following neoadjuvant chemotherapy with combined preoperative intraarterial infusion and intravenous chemotherapy is safe with similar morbidity of postoperative pneumonia to immediate surgery in patients with locally-advanced resectable gastric carcinoma.
