Influence of microsatellite instability on survival of patients with sporadic colorectal cancer in China.
- Author:
Xiao-feng WANG
1
;
Hei-ying JIN
;
Yi-jiang DING
;
Zhi-min FAN
;
Xiu-fang LIU
;
Jian-xiang GEN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; China; Colorectal Neoplasms; diagnosis; genetics; Female; Follow-Up Studies; Humans; Male; Microsatellite Instability; Middle Aged; Prognosis; Survival Rate
- From: Chinese Journal of Gastrointestinal Surgery 2011;14(7):520-523
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of microsatellite instability(MSI) in Chinese sporadic coloretal cancer.
METHODSA total of 146 patients with colorectal cancer were treated surgically from August 2004 to September 2006 in the Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine. Data were collected prospectively. Univariate and multivariable analyses were performed for parameters such as age, gender, tumor location, differentiation, MSI, tumor type, lymph node metastasis, TNM stage, and survival.
RESULTSFollow-up was available in 134 patients including telephone call and office visit. MSI(P=0.029), tumor type(P=0.000), TNM stage(P=0.000) were independently associated with survival on Cox regression model. There were 26 patients with MSI, and the 1-, 3-, and 5-year survival rates were 100%, 92.3%, and 92.3%, respectively. The remaining 108 patients had microsatellite stable tumor, and the 1-, 3-, and 5-year survival rates were 96.3%, 72.2%, and 63.5%, respectively. The difference was statistically significant(P=0.016).
CONCLUSIONMicrosatellite instability is an important factor associated with patient survival in Chinese sporadic colorectal cancer.
