Analysis for myeloperoxidase genetic polymorphism in gastric cancer.
- Author:
Qian WANG
1
;
Zhi-qiang YAN
;
Hai-bin WANG
;
Hai-tao XIE
;
Yang YU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Case-Control Studies; Female; Humans; Male; Peroxidase; genetics; Polymorphism, Genetic; Stomach Neoplasms; genetics
- From: Chinese Journal of Gastrointestinal Surgery 2011;14(7):542-544
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of myeloperoxidase(MPO) genetic polymorphism and gastric cancer.
METHODSA case-control study was performed including 62 patients with gastric cancer and 61 healthy controls. Peripheral blood was collected for genetic analysis of MPO-463.
RESULTSThere were no significant differences in gender, age, and smoking between the two groups(P>0.05). However, the two groups differed in drinking, family history of gastric cancer, and Helicobacter pylori(HP) infection(P<0.05). The frequencies of MPO-463GG, GA and AA were 87.1%, 11.3% and 1.6%in the study group, and were 72.1%, 23.0%, and 4.9% in the control group, respectively. Carriers of MPO-463 GA or AA had a significantly higher risk of gastric cancer than those of MPO-463 GG(χ(2)=4.253, P<0.05, OR=0.383, 95% CI: 0.151-0.972). Carriers of G allele had a significantly lower risk of gastric cancer compared to carriers of A allele(χ(2)=4.935, P<0.05, OR=0.399, 95% CI: 0.174-0.916).
CONCLUSIONMPO-463 G/A polymorphism is associated with gastric cancer with A being a protective gene.
