Association of schizophrenia with a promoter polymorphism in the dopamine D2 receptor gene.
- Author:
Dai-hui PENG
1
;
Gao-hua WANG
;
Zi-li CHENG
;
De-xin ZHANG
;
Kai-da JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Promoter Regions, Genetic; genetics; Receptors, Dopamine D2; genetics; Schizophrenia; diagnosis; genetics
- From: Chinese Journal of Medical Genetics 2005;22(1):94-95
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of -141C insert/delete polymorphism with schizophrenia in Wuhan of Hubei province.
METHODSA case-control study was conducted to analyze the polymorphism in the D(2) receptor gene promoter region with schizophrenia. A total of 120 cases of schizophrenia diagnosed according to CCMD-II R criteria and 100 normal controls were recruited in the study.
RESULTSIn this sample, the allele and genotype showed statistically significant differences between patients and normal controls (P<0.05).Especially, the frequency of -141C del was 11% in patients and 18% in control(OR 0.55, 95% CI 0.30-0.96; P<0.05). This allele was less common in schizophrenia than in normal controls (P<0.05).
CONCLUSIONThe -141C del polymorphism is associated with schizophrenia.The polymorphism may modify the association with other factors. Possibly -141C del in the DRD(2) promoter region is a strong candidate for a protective factor for this trait.
