Study of genetic polymorphism of 6 short tandem repeat loci in Nongqu Mongolian of inner Mongolia Autonomous Region in China.

Author: Shuping LIU ¹ ; Lifu BI ; Xiulan SU
Author Information

1. Research Center of Molecular Biology, Inner Mongolia Medical College, Huhehaote, Inner Mongolia Autonomous Region, 010059 P. R. China.
Publication Type:Journal Article
MeSH: Alleles; China; Electrophoresis, Polyacrylamide Gel; Gene Frequency; Genotype; Humans; Linkage Disequilibrium; Microsatellite Repeats; genetics; Polymerase Chain Reaction; Polymorphism, Genetic; genetics
From: Chinese Journal of Medical Genetics 2005;22(2):222-223
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo get the genotype and allele frequency distribution of 6 short tandem repeat (STR) loci VWA, FGA, PENTAE, D6S1043, D2S1772, D7S3048 in NongQu Mongolia of China.
METHODSTwo hundred and ninety-three unrelated individuals from Nongqu Mongolian were investigated. Polymerase chain reaction and polyacrylamide gel electrophoresis were used.
RESULTSEighty alleles and 335 genotypes were detected, with frequencies ranging from 0.0017 to 0.2828. All the 6 loci met Hardy-Weinberg equilibrium. The statistical analysis of 6 STR loci showed the heterozygosity (H) >/= 0.7945, the discrimination power (DP) >/= 0.9160, the probability of paternity exclusion (PPE) >/= 0.5919, and the polymorphic information content (PIC) >/= 0.7617.
CONCLUSIONThese results could serve as valuable data to enrich the Chinese genetic database and play an important role in Chinese population genetic forensic medical application.