Effect of the interaction between paranoxonase 1 and ATP-binding cassette transporter 1 gene polymorphism on serum lipid level.
- Author:
Zhi-jie XIAO
1
;
Shui-ping ZHAO
;
Sai NIE
;
Li-min TAN
;
Jun WU
;
Bo JIANG
;
Wei LU
Author Information
- Publication Type:Journal Article
- MeSH: ATP-Binding Cassette Transporters; genetics; Aged; Aryldialkylphosphatase; genetics; Base Sequence; Female; Genotype; Humans; Lipids; blood; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; genetics; Sequence Analysis, DNA
- From: Chinese Journal of Medical Genetics 2005;22(3):272-276
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the effect of interaction between paranoxonase 1 (PON1)gene polymorphism and ATP-binding cassette transporter 1 (ABCA1) genetic variation on serum lipid level.
METHODSPolymerase chain reaction-restricted fragments length polymorphism was used to determine PON1 A/B192 and ABCA1R219K genotype of 1019 subjects, including 680 patients with strokes and 339 healthy individuals as controls.
RESULTSNo significant association between A/B192 genotype and any of the lipid measurements was detected. The levels of HDL-C in the subjects with RR, RK and KK genotypes showed a significant upward tendency respectively (P < 0.05); the levels of their triglyceride (TG) tended downward respectively, but there were no significant differences between them. The relationship between R219K genotype and serum lipid level was modified by A/B192 genotype. The levels of HDL-C in the subjects with AA/RR genotype and BB/KK genotype [(1.41 +/- 0.40) mmol/L, (1.41 +/- 0.39) mmol/L] were significantly different from that in the subjects with BB/RR genotype [(1.28 +/- 0.36) mmol/L] (P < 0.05).
CONCLUSIONThe result exhibited an interaction of PON1 A/B192 and ABCA1 R219K on serum lipid level.
