Association between apolipoprotein A5 - 1131T > C polymorphism and susceptibility of coronary artery disease in Chinese.
- Author:
Yi-bo TANG
1
;
Ping SUN
;
Dong-ping GUO
;
Xiao-yu LI
;
Qi CHEN
;
Le-ming FAN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Apolipoprotein A-V; Apolipoproteins A; genetics; Asian Continental Ancestry Group; genetics; China; Coronary Artery Disease; blood; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; Humans; Lipids; blood; Logistic Models; Male; Middle Aged; Polymorphism, Single Nucleotide; genetics; Triglycerides; blood
- From: Chinese Journal of Medical Genetics 2005;22(3):281-283
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the relationship between apolipoprotein A5(apoA5) - 1131T > C polymorphism and the susceptibility of coronary artery disease (CAD) in Chinese.
METHODSThe restriction fragment length polymorphism of apoA5 gene - 1131T > C was studied using PCR in a case-control study which enrolled 235 patients with CAD diagnosed by angiography and 262 healthy controls from Jiangsu province.
RESULTSThe frequencies of T, C allele were 59.57%ì40.43% and 65.65%, 34.35% in CAD group and control group respectively. There was statistically significant difference in allele frequencies between CAD group and control group (P < 0.05). The susceptibility to CAD for the CC genotype was much higher than that for wild type TT (OR = 1.872, 95% CI = 1.039 - 3.376, P = 0.037), even after the use of Logistic regression models (OR = 2.285, 95% CI = 1.222 - 4.274, P = 0.012). In control group, there was significant difference in TG levels among different genotypes, the C allele carriers had higher serum TG concentration (P = 0.007).
CONCLUSIONapoA5 - 1131T > C polymorphism is associated with an increased risk of CAD and is also in strong association with serum TG levels.
