Study on the incidence of β-Thalassemia and genotypes among children under 7 year-olds in Nanning, Liuzhou and Baise areas, Guangxi province
10.3760/cma.j.issn.0254-6450.2009.010.009
- VernacularTitle:广西三城市7岁以下儿童β地中海贫血发生率及其基因突变类型的研究
- Author:
Xiao-Qiang QIU
1
;
Ping CHEN
;
Ning ZHANG
;
Xiao-Yun ZENG
;
Cai-Qian HUANG
;
Wen-Qiang CHEN
;
Wei-Xiong LIN
;
Shu-Quan LI
Author Information
1. 广西医科大学
- Keywords:
β-Thalassemia;
Genotypes;
Incidence rate;
Children
- From:
Chinese Journal of Epidemiology
2009;30(10):1021-1024
- CountryChina
- Language:Chinese
-
Abstract:
Objective To conduct research of β-Thalassemia incidence and genotypes on children below 7 years of age in Nanning, Liuzhou and Baise areas, Guangxi province. Methods A total of 2261 children aged below 7 in Nanning, Liuzhou and Baise areas were studied. Venous blood was detected by routine blood test, hemoglobin analysis and β-Thalassemia genotyping. Results Among 2261 samples, 125 showed high level of HbA2 and were diagnosed as β-Thalassemia (5.53%). Genotypes of the patients were classified as: 59 cases with β-globin gene eondon (CD) 41-42 mutation, 33 cases CD17 mutation, 18 cases with TA TA box nt-28 mutation, 7 with IVS-Ⅱ-654 mutation, 3 with CD43 mutation, 3 with HbE mutation, one with CD71-72 and TATA box nt-29 mutation, respectively. The genotyping frequencies of β-Thalassemia were as follows: 47.20% for CD41-42 mutation, 26.40% for CD17 mutation, 14.40% for TATAbox nt-28 mutation, 5.60% for IVS-Ⅱ -654 mutation, 2.40% for CD43 mutation, 2.40% for HbE mutation, 0.80% for CD71-72 mutation and TATAbox nt-29 mutation respectively. Conclusion This study on children in the area with high incidence of β-Thalassemia reflected the incidence and characteristics of genotypes in this area. Our data also provided evidence for the development of a program on genetic counseling and prevention for thalassemia.
