Comparison on the difference of virulence between Hantaan virus and Seoul virus isolated both from Rattus norvegicus

VernacularTitle:对分离自褐家鼠的汉滩型和汉城型病毒的毒力测定
Author: Zheng-Xiu DUAN ¹ ; Ming-Hui LI ; Juan YU ; Wen WANG ; Wen-Ping GUO ; Yong-Zhen ZHANG
Author Information

1. 石河子大学
Keywords: Hantavirus; Hantaan virus; Seoul virus; Virulence
From: Chinese Journal of Epidemiology 2009;30(10):1047-1050
CountryChina
Language:Chinese
Abstract: Objective Comparing the difference of virulence between the strain CGRn5310 (HTNV) and the strain HR54 (SEOV) isolated both from Rnttus norvegicus. Methods Suckling mice were used to compare the difference of virulence between the two strains. Hantavirus antigens were detected in brain and lung tissues collected from the infected mice. Results Compared with the control group, all infected mice grew slowly. Furthermore, the mice inoculated intracerebrally with either CGRn5310 or HR45 appeared ruffled fur, and reduced activity, followed by neurological symptoms, such as paralyses and convulsions. The half lethal dose (LD_(50)) of CGRn5310 strain was 10~-6.42, whereas the LD_(50) of HR54 strain was 10~-4.51. Hantavirus antigens were identified in brain and lung tissues from the mice infected with the strain CGRn5310 and the strain HR54. Conclusion LD_(50) of the strain CGRn5310 was significantly higher than that of the strain HR54. Our results suggested that the virulence of the spillover hantavirus might only slightly be influenced by the non-reservoir rodents.