Investigation on the source of the first human of avian influenza A (H5N1) case in Beijing
10.3760/cma.j.issn.0254-6450.2009.11.005
- VernacularTitle:北京市首例人禽流感H5N1病例的感染来源调查
- Author:
Peng YANG
1
;
Jian SHI
;
Jian-Xin MA
;
Xiu-Jun LIU
;
Shun-Xiang QI
;
Fang HUANG
;
Wei-Xian SHI
;
Xiao-Min PENG
;
Yan-Ning LV
;
Hui-Jie LIANG
;
Xin-Yu LI
;
Xiang-Feng DOU
;
Xiao-Li WANG
;
Yi ZHANG
;
Xing-Huo PANG
;
Xiong HE
;
Quan-Yi WANG
Author Information
1. 北京市疾病预防控制中心
- Keywords:
Avian influenza H5N1;
Infection source
- From:
Chinese Journal of Epidemiology
2009;30(11):1114-1116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the source of the first human case of avian influenza A (H5N1) infection in Beijing. Methods Interviewing the relatives of the case and other key persons, collecting and detecting samples of related biological, epidemiological and environmental data of the case were conducted. Later, the infection source was thoroughly investigated. Results The case ever contacted a slaughtered duck 5 days prior to the onset of illness, and the duck was bought from a stall of a wet market in Yanjiao area of Hebei province. Ten environmental samples were collected in this stall and the neighboring stall of the market. Another 6 samples were tested positive for H5N1 virus by PCR method, with 5 virus strains isolated. The whole-genome sequencing indicated that the amino acid homology between the H5N1 virus strains from the environment and the virus isolated from the case reached 99.8%-100%. Conclusion From both epidemiological and virological evidence, it was proved that the first human case of avian influenza A (H5N1) infection in Beijing was infected by a duck that carrying H5N1 virus the case contacted 5 days proceeding the onset of illness.
