The median survival and the effect of antiretroviral therapy among HIV-positive former blood donors in Anhui province
10.3760/cma.j.issn.0254-6450.2009.11.011
- VernacularTitle:安徽省既往献血员HIV感染后生存时间和抗病毒治疗效果研究
- Author:
Xia WANG
1
;
Xin-Ping DING
;
Bin SU
;
Chen XU
;
Yuan LIU
;
Yan-Min ZHANG
;
Jun-Ling ZHU
;
Li-Tao HAN
;
Yu-Hua RUAN
;
Yi-Ming SHAO
Author Information
1. 中国疾病预防控制中心
- Keywords:
Human immunodeficiency virus infection;
Former blood donors;
Median survival time;
Antiretroviral therapy
- From:
Chinese Journal of Epidemiology
2009;30(11):1135-1138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate the median survival and the effect of antiretroviral therapy (ART) among HIV-positive former blood donors of Fuyang in Anhui province, China. Methods A retrospective survey was conducted among HIV-positive former blood donors, and data was collected on survivors who had received ART. Weibull function was used to calculate median survival of HIV-positive former blood donors. The effect of ART was estimated through comparing the actual number of deaths after ART with the expected number of deaths in those who did not receive ART. Results The median period of HIV infection was at the end of 1994, with the median survival of HIV-positive former blood donors in Fuyang as 10.8 years. By the end of September 2008, among 159 former blood donors, 74 received ART, with their mean CD4+ T-cell count increased from 247.8/μl to 475.1/μl (P<0.0001). 76 of the 159 former blood donors died. When comparing the expected number of deaths calculated by Weibull function, 31.7% of the total number of deaths was reduced. Conclusion Result from this study was in consistent to the UNAIDS' figures that in the absence of treatment, the net median survival time after infection with HIV was estimated to be 11 years and ART has reduced about one third of the expected deaths.
