Study on patients with Creutzfeldt-Jakob disease in Shanghai, 2006-2012
10.3760/cma.j.issn.0254-6450.2013.09.009
- VernacularTitle:上海市2006-2012年克雅氏病病例监测
- Author:
Pu HUANG
1
;
Yi-Yi ZHU
;
Jia-Yu HU
;
Chen-Yan JIANG
;
Bo CHEN
;
Hong ZHANG
;
Jian CHEN
Author Information
1. 200336,上海市疾病预防控制中心急性传染病防治科
- Keywords:
Creutzfeldt-Jakob disease;
Surveillance;
Epidemiological characteristics
- From:Chinese Journal of Epidemiology
2013;34(9):897-899
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe the epidemiological characteristics of patients with Creutzfeldt-Jakob disease (CJD) in Shanghai from 2006 to 2012.Methods Clinical and epidemiological information on CJD patients from Shanghai CJD Surveillance Network was analyzed.Cerebral spinal fluid (CSF) and blood specimens from patients were collected and used for detecting the 14-3-3 protein,and polymorphism of 129 amino acid and mutation of PRNP genes.Data was processed by EpiData (V3.0) and analyzed by SPSS (V17.0).Results In totally,one definite CJD patient together with 56 probable and 17 possible sporadic CJD patients were identified.One E200K genetic CJD case was diagnosed and another one was clinically diagnosed.No period-or geographic-related events were observed for these cases,but the houses of the two genetic CJD cases were close to each other.The mean age of onset of the probable CJD patients was 62 years old which was significantly older than that of those possible CJD patients.Conclusion Most of the CJD patients identified in Shanghai were sporadic and the number was stable from 2006 to 2012.The mean age of onset of those probable CJD patients was older than that of the possible CJD patients.
