Association between intercellular adhesion molecule-1 K469E polymorphism and coronary heart disease in people with Uygur ethnicity, in Xinjiang.
- Author:
Jun-yi LUO
1
;
Yi-tong MA
2
;
Xiang XIE
1
;
Yi-ning YANG
1
;
Xiang MA
1
;
Zhen-yan FU
1
;
Xiao-mei LI
1
;
Zi-xiang YU
1
;
Bang-dang CHEN
3
;
Fen LIU
3
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Alleles; China; epidemiology; Coronary Disease; epidemiology; genetics; Ethnic Groups; genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Intercellular Adhesion Molecule-1; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors
- From:Chinese Journal of Epidemiology 2013;34(10):1018-1022
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the distribution on K469E single nucleotide polymorphism of ICAM-1 gene among people with Uygur ethnicity, in Xinjiang and to analyze the correlation between ICAM-1 gene polymorphism and coronary heart disease.
METHODS245 patients with coronary heart disease patients and 377 healthy controls in Xinjiang Uygur population were studied. ICAM-1 gene K469E genotype located in exon 6 were detected by polymerase chain reaction-restricted fragments length polymorphism.
RESULTSDistribution of genotypes in the two groups appeared to be in Hardy-Weinberg equilibrium (P > 0.05). The distribution of genotypes showed significant difference between the two groups (P = 0.039)and the distributions of K and E allele also presented statistically significant difference (P = 0.031). Significant difference was also observed in males(P = 0.029 for genotype, P = 0.025 for allele)but not in females. After adjusted for confounding factors, results from logistic regression analysis indicated that KK genotype was a risk factor for CHD in Uygur male population (OR = 2.389, 95% CI:1.458-3.915, P = 0.001).
CONCLUSIONGenetic polymorphism of ICAM-1 K469E might increase the risk for coronary artery disease in males of Uygur patients in Xinjiang.
