Roles of peroxisome proliferator-activated receptors polymorphisms, haplotypes, levels on C-reactive protein and their interactions with abnormal body weight
10.3760/cma.j.issn.0254-6450.2013.10.019
- VernacularTitle:过氧化物酶体增殖物激活受体多态性及其单体型对C反应蛋白的影响及与体重异常的交互作用
- Author:
Lu-Gang YU
1
;
Zheng-Yuan ZHOU
;
Zhi-Rong GUO
;
Ming WU
;
Shu-Jun GU
Author Information
1. 215021,苏州工业园区疾病防治中心
- Keywords:
Abnormal weight;
Peroxisome proliferator-activated receptors;
C-reactive protein;
Interaction
- From:
Chinese Journal of Epidemiology
2013;34(10):1023-1029
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the roles of peroxisome proliferator-activated receptors (PPARs) on the levels of serum C-reactive protein (CRP) and the interactions of PPARs haplotypes with abnormal body weight.Methods Subjects (n=644) were randomly selected from the cohort ‘Prevention of Multiple metabolic disorders and Metabolic syndrome in Jiangsu province (PMMJS)'Variance test,t test and lineal regression were used to analyze the associations between PPARs polymorphisms and the levels of CRP.The association between PPARs haplotypes and serum CRP levels as well as the interaction of PPARs haplotypes with abnormal body weight were analyzed,under the SNPStats software.Results After adjusting for sex,age,blood pressure,cigarette smoking,alcohol drinking and so on,data showed that both rs1800206 and rs9794 were associated with the changes along with the levels of CRP (P＜0.05).After adjusting for the same factors,haplotypes of AVG and CVG in PPARα,CG in PPARδ appeared to be associated with the increase (P＜0.05) while haplotypes of CC in PPARδ,CPCAC in PPARγ were associated with the decrease of CRP levels (P＜0.05).Results from the Interaction analysis also noted that the interactions did exist between abnormal body weight and both AVG,CVG in PPARαt,and CG in PPARδ.Conclusion PPARs polymorphisms and haplotypes were associated with CRP.Interaction between PPAR α/δand abnormal body weight might contribute to the levels of CRP.
