Optimization for vacuum belt drying process of Qibai Pingfei granule through response surface methodology.
- Author:
Xue-feng LI
;
Zhen-qiu XU
;
Ming YAN
;
Jing SHANG
;
Yan-jun ZHANG
;
Hui-juan MI
;
Wei XIAO
- Publication Type:Journal Article
- MeSH:
Chemistry, Pharmaceutical;
instrumentation;
methods;
Desiccation;
instrumentation;
methods;
Drugs, Chinese Herbal;
chemistry;
Plants, Medicinal;
chemistry;
Quality Control;
Temperature;
Vacuum
- From:
China Journal of Chinese Materia Medica
2015;40(20):3987-3992
- CountryChina
- Language:Chinese
-
Abstract:
Based on single factor tests,the optimum vacuum belt drying conditions of Qibai Pingfei granule were obtained through Box-Benhnken central combination design and RSM. In this study, drying time, drying temperature and extract density were chosen as independent variables, while transferring rate ginsenoside Rg₁, Re, Rb₁and astragaloside IV were taken as dependent variables. The optimum parameters are as follows: drying time of 112 min, drying temperature of 87 °C and extract density of 1.30 g · mL⁻¹. At the optimum condition, transferring rate ginsenoside Rg₁+ Re, Rb₁and astragaloside IV were 88.01%, 87.31%, 84. 34%. Above all, the optimum processing parameters of vacuum belt drying of Qibai Pingfei granule is reasonable and feasible, which can provide reliable basis for production.
