Cytotoxicity Of Denture Base Resins.
- Author:
Seong Kyun KIM
1
;
Ik Tae CHANG
;
Seong Joo HEO
;
Jai Young KEAK
Author Information
1. Department of Prosthodontics, Graduate School, Seoul National University. implant75@hanmail.net
- Publication Type:Original Article
- Keywords:
Denture base resin;
Cytotoxicity;
Metabolic assay;
Agar overlay test;
Mutagenicity
- MeSH:
Agar;
Denture Bases*;
Dentures*;
Immersion;
Mutagenesis;
Water
- From:The Journal of Korean Academy of Prosthodontics
2002;40(4):309-322
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this study was to investigate the cytotoxicity and mutagenicity of denture ase resins. According to manufacturer's instructions, resin specimens were made. Group 1: heat-polymerizing acrylic resin (Luciton 199(R)). Group 2: heat-polymerizing acrylic resin containing polyhedraloligosilsesquioxane(POSS esin). Group 3: auto-polymerizing acrylic resin (Repair Acrylic(R)). Group 4: direct relining auto-polymerizing acrylic resin (Tokuso Rebase(R)). Fresh specimens, 24 hrs. and 72 hrs. soaked specimens in distilled water were made. Responses with metabolic assay and mutagenesis assay to eluates from resin specimens were measured. Cultures with medium alone provided controls. Cytotoxicity was assessed with agar overlay test. The results were as follows: 1. Group 4 showed higher cytotoxicity than Group 1, Group 2 and Group 3 in fresh, 24-and 72-hour immersion cases (p<.05). Group 3 showed higher cytotoxicity than Group 2 in fresh cases and showed higher cytotoxicity than Group 1 and Group 2 in 24-and 72-hour immersion cases (p<.05). Group 1 and Group 2 showed no significant difference. 2. All acrylic denture base resins showed significant increase of cell activity as immersion time increased (p<.05). 3. Auto-polymerizing acrylic denture base resins showed higher cytotoxicity than heat-polymerizing acrylic denture base resins (p<.05). 4. All acrylic denture base resins showed lower mutagenicity than controls (p<.05).
