Changes to IFN-γ and IP-10 in the arterial blood of premature infants before and after mechanical ventilation.
- Author:
Min LI
1
;
Ying XIONG
;
De-Zhi MU
;
Hua WANG
Author Information
- Publication Type:Journal Article
- MeSH: Chemokine CXCL10; blood; physiology; Enzyme-Linked Immunosorbent Assay; Humans; Infant, Newborn; Infant, Premature; blood; Interferon-gamma; blood; physiology; Respiration, Artificial; Ventilator-Induced Lung Injury; etiology
- From: Chinese Journal of Contemporary Pediatrics 2012;14(7):496-498
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study examined changes to pro-inflammatory cytokine IFN-γ and chemokine IP-10 in the arterial blood of premature infants before and after mechanical ventilation, with the aim of exploring possible mechanisms of ventilation-induced lung injury.
METHODSTwenty-three neonates requiring mechanical ventilation were enrolled in this study. Arterial blood samples were collected for measuring IFN-γ and IP-10 levels using ELISA before and 4 hours after mechanical ventilation.
RESULTSBlood IFN-γ and IP-10 increased significantly from 59 ± 40 pg/mL and 130 ± 67 pg/mL respectively before mechanical ventilation to 105 ± 54 pg/mL and 220 ± 80 pg/mL respectively after 4 hours of mechanical ventilation (P<0.01).
CONCLUSIONSSerum IFN-γ and IP-10 levels increase after mechanical ventilation, suggesting that both may participate in the immune-inflammatory process of ventilation-induced lung injury.
