Re-evaluation of ABO gene polymorphisms detected in a genome-wide association study and risk of pancreatic ductal adenocarcinoma in a Chinese population.
- Author:
Hong-Li XU
1
;
Jia-Rong CHENG
;
Wei ZHANG
;
Jing WANG
;
Herbert YU
;
Quan-Xing NI
;
Harvey A RISCH
;
Yu-Tang GAO
Author Information
- Publication Type:Journal Article
- MeSH: ABO Blood-Group System; genetics; Adenocarcinoma; genetics; Aged; Alleles; Asian Continental Ancestry Group; genetics; Case-Control Studies; China; Confidence Intervals; Female; Gene-Environment Interaction; Genome-Wide Association Study; Genotype; Haplotypes; Humans; Male; Middle Aged; Odds Ratio; Pancreatic Neoplasms; genetics; Polymorphism, Single Nucleotide; Risk Factors
- From:Chinese Journal of Cancer 2014;33(2):68-73
- CountryChina
- Language:English
- Abstract: Pancreatic cancer is a fatal malignancy with an increasing incidence in Shanghai, China. A genome-wide association study (GWAS) and other work have shown that ABO alleles are associated with pancreatic cancer risk. We conducted a population-based case-control study involving 256 patients with pathologically confirmed pancreatic ductal adenocarcinoma (PDAC) and 548 healthy controls in Shanghai, China, to assess the relationships between GWAS-identified ABO alleles and risk of PDAC. Carriers of the C allele of rs505922 had an increased cancer risk [adjusted odds ratio (OR) = 1.42, 95% confidence interval (CI): 1.02-1.98] compared to TT carriers. The T alleles of rs495828 and rs657152 were also significantly associated with an elevated cancer risk (adjusted OR = 1.58, 95% CI: 1.17-2.14; adjusted OR = 1.51, 95% CI: 1.09-2.10). The rs630014 variant was not associated with risk. We did not find any significant gene-environment interaction with cancer risk using a multifactor dimensionality reduction (MDR) method. Haplotype analysis also showed that the haplotype CTTC was associated with an increased risk of PDAC (adjusted OR = 1.46, 95% CI: 1.12-1.91) compared with haplotype TGGT. GWAS-identified ABO variants are thus also associated with risk of PDAC in the Chinese population.
