Clinical Significance of p53 and Ki-67 Expression in Colorectal Cancer.
10.3393/jksc.2009.25.2.107
- Author:
Jung Wook HUH
1
;
Hyeong Rok KIM
;
Sang Hyuk CHO
;
Young Jin KIM
Author Information
1. Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Gwangju, Korea. drkhr@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
p53;
Ki-67;
Colorectal cancer
- MeSH:
Colorectal Neoplasms;
Humans;
Lymph Nodes;
Neoplasm Metastasis
- From:Journal of the Korean Society of Coloproctology
2009;25(2):107-112
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study aimed to evaluate the clinical significance of p53 and Ki-67 expressions in patients with colorectal cancer. METHODS: Immunohistochemical expressions of p53 and Ki-67 in 205 patients with colorectal cancer were examined. Results were correlated with clinical and pathological parameters. RESULTS: Overexpression of p53 was significantly associated with a proximal location of the tumor (P=0.031) and with lymph node involvement (P=0.030); however, Ki-67 expression was not correlated with any of the clinicopathological variables. Positive p53 staining was significantly associated with a higher level of Ki-67 (P=0.009). CONCLUSIONS: Overexpression of p53 was strongly correlated with lymph node metastasis in colorectal cancer; thus, p53 may be used as a possible prognostic marker in patients with colorectal cancer.
