Acute Fatty Liver of Pregnancy: two cases of favorable outcome.
- Author:
In Sook SOHN
1
;
Ji Yeon KIM
;
Han Sung KWON
;
Sun Ju LEE
;
Ji Young LEE
;
Soo Nyung KIM
;
Won Hyeok CHOE
;
Nam Sik WOO
;
Hye Seung HAN
Author Information
1. Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Korea. sohnis@kuh.ac.kr
- Publication Type:Case Report
- Keywords:
Acute fatty liver of pregnancy;
Liver biopsy;
Anesthesia
- MeSH:
Abdominal Pain;
Acute Kidney Injury;
Anesthesia;
Anesthesia, General;
Biopsy;
Cesarean Section;
Diarrhea;
Disseminated Intravascular Coagulation;
Emergencies;
Fatty Liver*;
Female;
Fetal Distress;
Hepatocytes;
Humans;
Jaundice;
Liver;
Pregnancy Trimester, Third;
Pregnancy*;
Pregnant Women;
Prognosis
- From:Korean Journal of Obstetrics and Gynecology
2006;49(12):2604-2611
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acute fatty liver of pregnancy is a rare but usually fatal complication of the last trimester of pregnancy. The primary therapy is early delivery and supportive care. We report two cases of favorable outcomes in acute fatty liver of pregnancy. First case was a nulliparous twin pregnant woman at 33 weeks of gestation with jaundice, abdominal pain, and diarrhea. Because the acute fatty liver of pregnancy was diagnosed by typical laboratory findings, an emergency cesarean section was performed. Then, she showed the symptoms of acute renal failure, and the laboratory findings of disseminated intravascular coagulation. Second case was a nulliparous women at 37 weeks of gestation with malaise, upper abdominal pain, and elevated transaminase level. Under the impression of the acute fatty liver of pregnancy and fetal distress, an emergency cesarean section was performed under both epidural and general anesthesia. Liver biopsy was performed and showed microvesicular fatty infiltration of hepatocyte. In spite of the literature's dismal prognosis, our cases seemed to be favorable maternal and perinatal outcomes because of early recognition and immediate termination of pregnancy with intensive and supportive care.
