Antigen-antibody reaction model of solid-phase surface and active biochip system.
- Author:
Wenwei ZHU
1
;
Wenhong ZHANG
;
Wenbiao ZHU
;
Fengchan HAN
;
Xiuzhen DONG
;
Xiaojun YAN
Author Information
1. Institute of Genetic Diagnosis, The Fourth Military Medical University, Xi'an 710032, China. zhuwenwei428@hotmail.com
- Publication Type:Journal Article
- MeSH:
Antigen-Antibody Reactions;
Biosensing Techniques;
instrumentation;
Equipment Design;
Models, Biological
- From:
Journal of Biomedical Engineering
2006;23(4):739-742
- CountryChina
- Language:Chinese
-
Abstract:
To overcome the present limitations of passive biochip, based on the basic principle of antigen-antibody reaction, we develop an antigen-antibody reaction model of solid-phase surface and design a novel active biochip system according to this model, which introduces the negative pressure and controlling devices to control the immunoreactions on the nitrocellulose (NC) membrane. From the computer simulation results, this is a rapid, stable, robust and practicable system, which can be used to increase the efficiency of immunoreactions and improve the reproducibility and accuracy of biochip analysis.
