Effects of extracts from different parts of Folium perillae (L.) Britt. on Hemorrheological parameters in rats.
- Author:
Zaipin XU
1
;
Xiaoyan DENG
;
Jiying MEN
;
Xuejian FENG
;
Zhanjun LU
;
Qinghua YANG
;
Biqiong YAO
Author Information
1. Key Lab for Biomechanics & Tissue Engineering of Ministry of Education, Chongqing University, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Blood Viscosity;
drug effects;
Erythrocyte Aggregation;
drug effects;
Erythrocyte Deformability;
drug effects;
Male;
Perilla frutescens;
anatomy & histology;
chemistry;
Plant Extracts;
pharmacology;
Plant Leaves;
chemistry;
Plant Stems;
chemistry;
Random Allocation;
Rats;
Rats, Wistar;
Seeds;
chemistry
- From:
Journal of Biomedical Engineering
2006;23(4):762-765
- CountryChina
- Language:Chinese
-
Abstract:
In order to provide experimental data for the development and application of drug in clinic, we determined the effects of extracts from different parts of folium perillae (L. ) Britt. on hemorheological parameters, extracted from leaves (folium perillae), seeds (fructus perillae) and peduncles (caulis perillae). The results showed that all extracts from different parts of folium perillae (L. ) Britt. can significantly reduce the whole blood viscosity at low shear rate (10 s(-1)), erythrocyte aggregation index, erythrocyte electrophoresis index (P<0.05), and the whole blood reductive viscosity at low shear rate (10 s(-1)) (P<0.01). Extracts from folium perillae and caulis perillae can significantly decrease erythrocyte deformation index (P<0.05), whereas extracts from fructus perillae can not. Extracts from fructus perillae and caulis perillae can significantly decrease plasma viscosity at low shear rate(10 s(-1)), but extracts of folium perillae can not. Aspirin can only decrease the whole blood reductive viscosity at low shear rate and plasma viscosity (P<0.05). All extracts from different parts of folium perillae (L. ) Britt. had no significant effects on hematocrit, erythrocyte rigidity index, fibrinogen concentration , the whole blood viscosity and the whole blood reductive viscosity at middle and high shear rate (60 s(-1),120 s(-1)).
