Preparation and characterization of magnetic nano-particles with radiofrequency-induced hyperthermia for cancer treatment.
- Author:
Xiangshan FAN
1
;
Dongsheng ZHANG
;
Jie ZHENG
;
Ning GU
;
Anwei DING
;
Xiupeng JIA
;
Hongyun QING
;
Liqiang JIN
;
Meiling WAN
;
Qunhui LI
Author Information
1. Department of Pathology and Pathophysiology, Institute of Molecular Pathology, Medical School Southeast University, Nanjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Line;
Ferrous Compounds;
Hyperthermia, Induced;
Magnetics;
instrumentation;
therapeutic use;
Manganese;
Materials Testing;
Mice;
Nanostructures;
Zinc
- From:
Journal of Biomedical Engineering
2006;23(4):809-813
- CountryChina
- Language:Chinese
-
Abstract:
Mn0.5Zn0.5Fe2O4 nano-particles were prepared by the chemical co-precipitation, their characteristics were observed with transmission electron microscope (TEM), X-ray diffractometer (XRD) and thermal analysis system, and etc. The temperature changes of the nano-particles of Mn0.5Zn0.5Fe2O4 and its magnetic fluid explored in radiofrequency(RF,200 KHz, 4 KW) were measured. The proliferation ratio of L929 cells cultured in soak of Mn0.5Zn0.5Fe2O4 nano-particles were observed. The experiment indicates that the magnetic particles were about 40 nm diameter in average, round, had strong magnetism, and were proved to be consistent with the standard data of chart of XRD. Its magnetic fluid exposed to RF could be heated up to temperature range from 40 degrees C to 51 degrees C due to the amount of the magnetic nano-particles and intensity of the alternating magnetic field. Magnetic nano-particles were found to have no obvious cytotoxicity to L929 cells.
