Ras-MAPK signaling pathway activated via brain-derived neurotrophic factor.
- Author:
Xiaomei SUN
1
;
Meng MAO
Author Information
1. West China Second University Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Brain-Derived Neurotrophic Factor;
pharmacology;
physiology;
Calcium-Calmodulin-Dependent Protein Kinase Type 2;
Calcium-Calmodulin-Dependent Protein Kinases;
drug effects;
physiology;
Cells, Cultured;
Humans;
Mitogen-Activated Protein Kinases;
drug effects;
physiology;
Neurons;
cytology;
drug effects;
enzymology;
Signal Transduction
- From:
Journal of Biomedical Engineering
2006;23(4):915-918
- CountryChina
- Language:Chinese
-
Abstract:
Brain-derived neurotrophic factor (BDNF)is the richest neurophin in brain tissue and may act as an activity-dependent neuronal survival factor. In vitro, BDNF plays an important role in preventing cortical neurons from hypoxia-induced neurotoxicity. It could induce a variety of cellular responses such as cell growth, survival, differentiation, and anti-apoptosis mainly via activating mitogen-activated protein kinase (MAPK) and Ca2+/calmodulin-dependent kinase (CaMK) signaling pathways. And among these multiple signaling pathways there is growing evidence of complicated cross talk.
