Experimental study on the migration of vascular endothelial cells stimulated by IL-8.
- Author:
Minjun ZOU
1
;
Xiaoheng LIU
;
Yi LI
;
Yi LAI
Author Information
1. Institute of Biomedical Engineering, West China Medical Center, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Cell Movement;
drug effects;
Cells, Cultured;
Dose-Response Relationship, Drug;
Endothelial Cells;
cytology;
drug effects;
Endothelium, Vascular;
cytology;
Humans;
Interleukin-8;
administration & dosage;
pharmacology
- From:
Journal of Biomedical Engineering
2006;23(5):1013-1016
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the influence of different concentrations of IL-8 on the migration of vascular endothelial cells and find out the best IL-8 concentration, the transwell chamber motility assay and the scrape motility assay were applied to observe the migration of vascular endothelial cells induced by IL-8. The results demonstrated that the migration of vascular endothelial cells was increased significantly under different IL-8 concentrations, while the best effect occurred when IL-8 concentration was 100 ng/ml.
