Preparation of cytarabine nanoparticle and study on the drug releasing mechanism.
- Author:
Jing ZHOU
1
;
Shu LIN
;
Xuehua JIANG
;
Junyi YANG
Author Information
1. School of Pharmacy, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cytarabine;
pharmacokinetics;
Delayed-Action Preparations;
Drug Compounding;
methods;
Nanoparticles;
Rabbits
- From:
Journal of Biomedical Engineering
2006;23(5):1066-1069
- CountryChina
- Language:Chinese
-
Abstract:
Cytarabine nanoparticle was prepared through emulsion polymerization method, and its releasing properties were studied. The results showed that releasing principle complied with biexponential equation and had characteristics of sustained releasing. The pharmacokinetics in rabbits complied with two-department model. Compared with cytarabine injection, cytarabine nanoparticle had prolonged t 1/2beta and MRT and reduced CL, which showed nanoparticle could significantly prolong the retention time of Ara-C and possess significant sustained releasing character.
