Clustering of inflammatory biomarkers and risk of hypertension in a Mongolian population in China.
- Author:
Xiao Hong ZHU
;
Yang JIAO
;
Hong Mei LI
;
Ai Li WANG
;
Gui Yan WANG
;
Wei Jun TONG
;
Yong Hong ZHANG
- Publication Type:Letter
- MeSH: Adult; Aged; Aged, 80 and over; Angiotensin II; genetics; metabolism; Asian Continental Ancestry Group; C-Reactive Protein; genetics; metabolism; China; Female; Genetic Markers; Genetic Predisposition to Disease; Humans; Hypertension; genetics; Inflammation; genetics; metabolism; Intercellular Adhesion Molecule-1; genetics; metabolism; Male; Middle Aged; Young Adult
- From: Biomedical and Environmental Sciences 2012;25(5):562-568
- CountryChina
- Language:English
-
Abstract:
OBJECTIVEThere is little knowledge on whether there is clustering of inflammatory biomarkers, such as C-reactive protein (CRP), soluble intracellular adhesion molecule1-1 (sICAM-1), and angiotensin II (Ang II), in individuals with hypertension in the Mongolian population. In the present study, we investigated this relationship in a Mongolian population in China.
METHODSA total of 2589 adult Mongolians, aged 20 years and older, were recruited as study participants. Data on demographics, lifestyle, family history of hypertension, blood pressure, and blood chemistry were collected, and inflammatory biomarkers were measured in all participants.
RESULTSThe proportion of subjects with increased levels of two or three biomarkers was significantly higher in those with hypertension (21.0% and 6.0%, respectively) than in those with prehypertension (12.7% and 0.5%, respectively) or normotension (8.1% and 0.2%, respectively). The multivariate adjusted odds ratios (95% confidence interval) of hypertension associated with increased levels of one, two or three biomarkers were 0.94 (0.72-1.22), 1.42 (0.93-2.16), and 11.08 (1.45-84.80), respectively, compared with subjects with no increase in any biomarker.
CONCLUSIONHypertension was associated with a cluster of inflammatory biomarkers in the Mongolian population.