Dexamethasone Induced Cardiac Hypertrophy in Preterm Infants hypertrophy, Hypertrophic Cardiomyopathy.
- Author:
Young Na HAN
1
;
Sang Hyon PARK
;
Gi Young JANG
;
Chang Sung SON
;
Joo Won LEE
;
Young Chang TOCKGO
Author Information
1. Department of Pediatrics, College of Medicine, Korea University, Korea.
- Publication Type:Original Article
- Keywords:
Dexamethasone;
Bronchopulmonary dysplasia;
Cardiac hypertrophy;
Hypertrophic Cardiomyopathy
- MeSH:
Arterial Pressure;
Bronchopulmonary Dysplasia;
Cardiomegaly*;
Cardiomyopathy, Hypertrophic*;
Dexamethasone*;
Echocardiography;
Follow-Up Studies;
Heart Rate;
Humans;
Hypertension;
Hypertrophy*;
Infant;
Infant, Newborn;
Infant, Premature*;
Korea;
Retrospective Studies
- From:Journal of the Korean Pediatric Cardiology Society
2001;5(1):34-41
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Dexamethasone is a well-known treatment for preterm infants with bronchopulmonary dysplasia. However, serious side effects have been identified, including hypertension, and cardiac hypertrophy. This study was undertaken to examine whether dexamethasone induced cardiac hypertrophy in preterm infants with bronchopulmonary dysplasia. METHODS: We retrospectively reviewed 12 infants with bronchopulmonary dysplasia treated with dexamethasone at Korea University Hospital from August 1995 to February 1999. Serial two-dimensional and M-mode echocardiographic measurements were taken before treatment and at 1,2,3,4,5 weeks after the start of dexamethasone therapy. RESULTS: Patients receiving dexamethasone had a significantly increase in interventricular septal thickness and left ventricular posterior wall thickness. These effects were transient, reached their maximal degree by the third week of treatment, and approached pretreatment conditions by the fifth week of treatment. Heart rate was increased but statistically not significant. The fractional shortening, systolic and diastolic arterial pressure were transiently increased during dexamethasone therapy. CONCLUSION: We conclude that a transient myocardial hypertrophy is associated with dexamethasone therapy in infants with bronchopulmonary dysplasia. Follow up of careful echocardiac monitoring should be considered in infants with dexamethasone therapy.
