Effect of yirong oral liquid on the reperfusion injury in rats with cerebral infarction undergoing thrombolysis.
- Author:
Xue-gong FENG
1
;
Mao-cai LIU
;
Jing-bo SUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cerebral Infarction; drug therapy; pathology; Drug Therapy, Combination; Drugs, Chinese Herbal; therapeutic use; Male; Malondialdehyde; blood; Neuroprotective Agents; therapeutic use; Phytotherapy; Rats; Rats, Sprague-Dawley; Reperfusion Injury; prevention & control; Superoxide Dismutase; blood; Thrombolytic Therapy; Urokinase-Type Plasminogen Activator; therapeutic use
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(2):143-146
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Yirong Oral Liquid (YROL) on reperfusion injury in rats with cerebral infarction undergoing thrombolysis.
METHODSClinical reperfusion under thrombolysis was simulated by applying thrombolysis on reversible local cerebral ischemic rat model. In the rat model, effect of YROL on parameters concerning anti-oxidation capability, cerebral edema and ultrastructure of brain were observed.
RESULTSYROL could alleviate the cerebral edema after reperfusion, markedly increase the activity of superoxide dismutase in blood plasma, decrease the content of malonyldialdehyde, inhibit the post-reperfusion lipid peroxidation, and significantly reduce the ischemia/reperfusion injury of nerve cells in brain of rat.
CONCLUSIONYROL has definite protecting effect on brain.
