Relationship between pathological development of phlegm-stasis and expression of actin in vascular smooth muscle cell in atherosclerosis rat model.
- Author:
Dong-sheng WANG
1
;
Zhao-kai YUAN
;
Fang-ping CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Actins; biosynthesis; Animals; Arteriosclerosis; complications; metabolism; pathology; Diagnosis, Differential; Female; Hyperlipidemias; blood; complications; pathology; Male; Medicine, Chinese Traditional; Muscle, Smooth, Vascular; metabolism; Random Allocation; Rats; Rats, Wistar
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(3):234-237
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the dynamic change of Phlegm-stasis in the rat atherosclerotic model as the time goes on.
METHODSAdopting high fat forage fed to develop the atherosclerotic model in rats, and the changes of blood lipid, hemorrheology, blood glucose, insulin and vascular smooth muscle cell (VSMC) actin expression were detected by biochemical and immunohistochemical assay at various time points after modeling.
RESULTSThe expression of VSMC actin gradually increased along with the change of model rats' Syndrome from Phlegm to stasis, i.e., the change of parameters, including blood lipid, hemorrheologic parameters, blood glucose, insulin and insulin sensitive indexes along with the aggravation of disease.
CONCLUSIONThe expression of VSMC actin could be the molecular mechanism for the Syndrome developing from Phlegm to stasis in atherosclerotic rats.
