Predictive value of (99)Tc(m)-MIBI scintimammography in evaluation of the efficacy of neoadjuvant chemotherapy in patients with operable breast cancer.
- Author:
Zhen-zhen LIU
1
;
Zhen-duo LU
;
Heng-wei ZHANG
;
Hui YANG
;
Hui LIU
;
Lian-fang LI
;
Wen-Liang LI
;
Shu-de CUI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Breast Neoplasms; diagnostic imaging; drug therapy; Carcinoma, Ductal, Breast; diagnostic imaging; drug therapy; Carcinoma, Lobular; diagnostic imaging; drug therapy; Chemotherapy, Adjuvant; Cyclophosphamide; therapeutic use; Disease-Free Survival; Epirubicin; therapeutic use; Etoposide; therapeutic use; Female; Fluorouracil; therapeutic use; Follow-Up Studies; Humans; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Predictive Value of Tests; Radionuclide Imaging; Radiopharmaceuticals; Remission Induction; Taxoids; therapeutic use; Technetium Tc 99m Sestamibi
- From: Chinese Journal of Oncology 2011;33(7):544-546
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the value of technetium-99m methoxyisobutylisonitrile ((99)Tc(m)-MIBI) imaging in predicting the efficacy of neoadjuvant chemotherapy (NCT) and prognosis in patients with operable breast cancer.
METHODSSixty five patients with breast cancer underwent (99)Tc(m)-MIBI scintimammography before NCT, and static planar images were taken at 10 min and 180 min after scintimammography. The clearance rate was calculated in each patient, correlation between the clearance rate and efficacy of NCT, and the disease free survival rate were analyzed.
RESULTSThe mean clearance rate of 65 patients was (17.4 ± 6.8)%. The efficacy of NCT was 86.2% (CR 4 cases, PR 52 cases, SD 8 cases, and PD 1 case), and the mean clearance rate of patients with good response or poor response of chemotherapy were (15.5 ± 5.0)% and (29.2 ± 3.2)%, respectively. There was a significant difference between the two groups. The average disease free survival rate in the group with low clearance rate was (75.8%, P = 0.046), significantly higher than that in the group with high clearance rate (53.1%).
CONCLUSIONScintimammography of (99)Tc(m)-MIBI may be used to evaluate the efficacy and prognosis of NCT for patients with operable breast cancer.
