Multi-factor analysis of radiation-induced esophagitis in three-dimensional conformal radiotherapy for non-small cell lung cancer.
- Author:
Tao GU
1
;
Hai-xia HUA
;
Zhan-zhao FU
;
Shao-hua ZHANG
;
Xiao-yan CAO
;
Qing-huai ZHANG
;
Sen YANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Carcinoma, Non-Small-Cell Lung; radiotherapy; Esophagitis; etiology; Esophagus; pathology; Female; Follow-Up Studies; Humans; Lung Neoplasms; radiotherapy; Male; Middle Aged; Multivariate Analysis; Radiation Injuries; etiology; Radiation Tolerance; Radiotherapy Dosage; Radiotherapy, Conformal; adverse effects; methods; Retrospective Studies
- From: Chinese Journal of Oncology 2011;33(11):868-871
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the clinical and physical factors that might give rise to radiation-induced esophagitis in three-dimensional conformal radiotherapy for non-small cell lung cancer.
METHODSTo collect the clinical and physical records and follow-up information of 106 NSCLC patients without undergoing surgery in our hospital. χ(2) test, linear tendency test and analysis of variance were employed to analyze the relationship between occurrence of radiation-induced esophagitis and clinical and physical treatment. Logistic analysis was also used for multivariate analysis.
RESULTSAmong the 47 cases of radiation-induced esophagitis, 31 cases were of grade I, 11 of grade II, 5 of grade III, and with a total occurrence rate of 44.3% (47/106). Radiation-induced esophagitis was correlated with Karnofsky scores, radiation sensitization and tumor location (χ(2) = 11.30, 8.45, 7.67, P < 0.05). Radiation-induced esophagitis was correlated with the length of irradiated esophagus and average dose of irradiated esophagus (F = 20.82, 83.08, P < 0.001). With the increase of the irradiated volume percentage from V20, V30, V40 up to V50, the occurrence rate of radiation-induced esophagitis was also increased, almost with a linear trend (P < 0.05). Application of all the above factors to logistic model indicated that radiation sensitization,length of irradiated esophagus, average dose and V50 were all statistically significant foactors in the occurrence of radiation-induced esophagitis (OR = 0.321, 2.850, 7.307 and 8.558, P < 0.05).
CONCLUSIONSRadiation sensitization,length of irradiated esophagus, average dose of irradiated esophagus and V50 are independent factors in the occurrence of radiation-induced esophagitis. V50 is of greater importance in the judgement of occurrence of radiation-induced esophagitis.