Association between CTLA-4 gene polymorphism and susceptibility to cervical cancer.
- Author:
Hua LI
1
;
Yi-feng ZHOU
;
Hong-yan GUO
;
Tong SUN
;
Wen-hua ZHANG
;
Dong-xin LIN
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; genetics; metabolism; pathology; surgery; Adult; Aged; Alleles; CTLA-4 Antigen; genetics; metabolism; Carcinoma in Situ; genetics; metabolism; pathology; surgery; Carcinoma, Squamous Cell; genetics; metabolism; pathology; surgery; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Middle Aged; Neoplasm Staging; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Risk Factors; Uterine Cervical Neoplasms; genetics; metabolism; pathology; surgery
- From: Chinese Journal of Oncology 2011;33(9):681-684
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between CTLA-4 +49A/G polymorphisms and the risk of susceptibility to cervical cancer.
METHODSA hospital-based case-control study was conducted. 314 cases with primary cervical cancer and 320 healthy controls were collected and genotyped by PCR-based RFLP for +49A/G polymorphisms in the CTLA-4 gene.
RESULTSThe A allele and AA genotype of CTLA-4 gene were 32.5% and 9.6% in the patients, and 25.8% and 5.6% in the controls, respectively. Subjects with CTLA-4 +49AA genotype conferred a higher risk of cervical cancer (OR = 2.06, 95%CI: 1.10 - 3.85; P = 0.024). However, the correlation between AA genotype in CTLA-4 polymorphisms and clinicopathological characteristics was not significant.
CONCLUSIONThe results of this study suggest that CTLA4 gene is associated with cervical cancer risk and may be a susceptible gene of cervical cancer.
