A new indole derivative from endophyte Myrothecium roridum IFB-E091 in Artemisia annua.
- Author:
Li SHEN
;
Ling-yu LI
;
Xiao-jun ZHANG
;
Ming LI
;
Yong-chun SONG
- Publication Type:Journal Article
- MeSH:
Artemisia annua;
microbiology;
Cell Line, Tumor;
drug effects;
Endophytes;
chemistry;
Humans;
Hypocreales;
chemistry;
Indoles;
chemistry;
isolation & purification
- From:
Acta Pharmaceutica Sinica
2015;50(10):1305-1308
- CountryChina
- Language:Chinese
-
Abstract:
Three compounds were isolated from solid culture of endophyte Myrothecium roridum IFB-E091 in Artemisia annua. Their structures were determined as (S)-(-)-N-[2-(3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-acetamide (1), N-(4-hydroxyphenethyl)acetamide (2) and asperfumoid (3), in which compound 1 was a new indole derivative. In cytotoxicity assay, the compound 1 had no obvious inhibition activity in human hepatoma cell line SMMC-7721 and human cervical carcinoma cell line HeLa.
