The absorption and metabolism of oxymatrine in rat intestine.
- Author:
Li-yun CAI
;
Li-li WU
;
Xiao-ming YU
;
Jun-jin LIU
;
Wei-chao HAN
;
Qiang WEI
;
Lan TANG
- Publication Type:Journal Article
- MeSH:
Alkaloids;
metabolism;
Animals;
Chromatography, High Pressure Liquid;
Intestinal Absorption;
Intestines;
metabolism;
Quinolizines;
metabolism;
Rats;
Spectrometry, Mass, Electrospray Ionization
- From:
Acta Pharmaceutica Sinica
2015;50(10):1336-1341
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of this study is to systematically investigate the characteristics of absorption and metabolism of oxymatrine (OMT) using rat intestinal perfusion model. Ultra performance liquid chromatography (UPLC) and high performance liquid chromatography-electrospray ionization-quadrupole-time of flight mass spectrometry (HPLC-ESI(+)-Q-TOF-MS) were used to test absorption of OMT in intestine at 100, 200 and 400 µmol · L(-1). The absorption rate and permeability of OMT is not dependent on concentration, but through passive absorption in intestine (P > 0.05). In the rat intestine, the absorbed amount of OMT was significantly different in four sections of the intestine in an order of duodenum > jejunum > ileum > colon (P < 0.05). OMT is metabolized into two metabolites in duodenum and jejunum, and matrine (MT) is the major one.
