Determination of contact angle of pharmaceutical excipients and regulating effect of surfactants on their wettability.
- Author:
Dong-dong HUA
;
He-ran LI
;
Bai-xue YANG
;
Li-na SONG
;
Tiao-tiao LIU
;
Yu-tang CONG
;
San-ming LI
- Publication Type:Journal Article
- MeSH:
Chemistry, Pharmaceutical;
Excipients;
chemistry;
Hydrophobic and Hydrophilic Interactions;
Surface-Active Agents;
chemistry;
Tablets;
Water;
Wettability
- From:
Acta Pharmaceutica Sinica
2015;50(10):1342-1345
- CountryChina
- Language:Chinese
-
Abstract:
To study the effects of surfactants on wettability of excipients, the contact angles of six types of surfactants on the surface of two common excipients and mixture of three surfactants with excipients were measured using hypsometry method. The results demonstrated that contact angle of water on the surface of excipients was associated with hydrophilcity of excipients. Contact angle was lowered with increase in hydrophilic groups of excipient molecules. The sequence of contact angle from small to large was starch < sodium benzoate < polyvinylpyrrolidone < sodium carboxymethylcellulose < sodium alginate < chitosan < hydroxypropyl methyl cellulose
